In many cases the Astoria2 is easier to run: (1) Segmentation bubbles allow for a “visual” QC of the system before, during and after a run. (2) Sample volumes are determined by sampling time (adjusted in Astoria software) vs. sample injection loops (which need to be physically changed out from the FIA Injection Valve). (3) The Astoria flowcells are easier to access and can be inspected during system operation. (4) The Astoria2 does not require a separate heating module (like FIA has) for reactions requiring a heat bath. And (5) the Astoria2 does not require an Injection Valve (like FIA does), which can wear out quickly and can be expensive to replace.